Step
2: Reverse Transcription
HIV's genes are
carried in two strands of RNA, while the
genetic material of human cells is found
in DNA. In order for the virus to infect
the cell, a process called "reverse
transcription" makes a DNA copy of
the virus's RNA.
After the binding process, the viral capsid
(the inside of the virus which contains
the RNA and important enzymes) is released
into the host cell. A viral enzyme called
reverse transcriptase makes a DNA copy
of the RNA. This new DNA is called "proviral
DNA."
Step
3: Integration
The HIV DNA is then
carried to the cell's nucleus (center),
where the cell's DNA is kept. Then, another
viral enzyme called integrase hides the
proviral DNA into the cell's DNA. Then,
when the cell tries to make new proteins,
it can accidentally make new HIVs.
Step
4: Transcription
Once HIV's genetic
material is inside the cell's nucleus,
it directs the cell to produce new HIV.
The strands of viral DNA in the nucleus
separate, and special enzymes create a
complementary strand of genetic material
called messenger RNA or mRNA (instructions
for making new HIV).
Step
5: Translation
The mRNA carries
instructions for making new viral proteins
from the nucleus to a kind of workshop
in the cell. Each section of the mRNA
corresponds to a protein building block
for making a part of HIV.
As each mRNA strand is processed, a corresponding
string of proteins is made. This process
continues until the mRNA strand has been
transformed or "translated"
into new viral proteins needed to make
a new virus.
Step
6: Viral Assembly
Finally,
a new virus is assembled. Long strings
of proteins are cut up by a viral enzyme
called protease into smaller proteins.
These proteins serve a variety of functions;
some become structural elements of new
HIV, while others become enzymes, such
as reverse transcriptase.
Once the new viral particles are assembled,
they bud off the host cell, and create
a new virus. This virus is then able to
infect new cells. Each infected cell can
produce a lot of new viruses.